Canine Diabetes

Annabessacook Veterinary Clinic
417 Route 135
Monmouth, Maine 04259
(207)933-2165
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Diabetes Mellitus in Dogs

There are two forms of diabetes in dogs: diabetes insipidus and diabetes mellitus. Diabetes insipidus is a very rare disorder that results in failure to regulate body water content. Your dog has the more common type of diabetes: diabetes mellitus. This is a fairly common disorder and is most often seen is dogs 5 years of age or older. There is a congenital form that occurs in puppies, but this is not common.

Diabetes mellitus is a disease of the pancreas. This is a small but vital organ that is located near the stomach. It has two significant populations of cells. One group of cells produces the enzymes necessary for proper digestion. The other group, called beta-cells, produces the hormone called insulin. Simply put, diabetes mellitus is a failure of the pancreas to regulate blood sugar.

The Types of Diabetes

In humans, two types of diabetes mellitus have been discovered. Both types are similar in that there is a failure to regulate blood sugar, but the basic mechanisms of disease differ somewhat between the two groups.

1. Type I, or Insulin Dependent Diabetes Mellitus, results from total or near-complete destruction of the beta-cells. This is the only type of diabetes known in dogs. As the name implies, dogs with this type of diabetes require insulin injections to stabilize blood sugar.

2. Type II, or Non-Insulin Dependent Diabetes Mellitus, is different because some insulin-producing cells remain. However, the amount produced is insufficient, there is a delayed response in secreting it, and the tissues of the dogs body are relatively resistant to it. People with this form may be treated with an oral drug that stimulates the remaining functional cells to produce or release insulin in an adequate amount to normalize blood sugar. Because Type II diabetes does not occur in dogs, oral medications are not appropriate for treating diabetic dogs.

The Purpose of Insulin

The role of insulin is much like that of a gatekeeper: it stands at the surface of body cells and opens the door, allowing glucose to leave the blood stream and pass inside the cells. Glucose is a vital substance that provides much of the energy needed for life, and it must work inside the cells. Without an adequate amount of insulin, glucose is unable to get into the cells. It accumulates in the blood, setting in motion a series of events that can ultimately prove fatal.

When insulin is deficient, the cells become starved for a source of energy. In response to this, the body starts breaking down stores of fat and protein to use as alternative energy sources. As a consequence, the dog eats more; thus, we have weight loss in a dog with a ravenous appetite. The body tries to eliminate the excess glucose by excreting it in the urine. However, glucose (blood sugar) attracts water; thus, urine glucose takes with it large quantities of the body's fluids, resulting in the production of a large amount of urine. To avoid dehydration, the dog drinks more and more water. Thus, we have the four classical signs of diabetes:

CLASSICAL SIGNS OF DIABETES MELLITUS:

Weight loss
Ravenous appetite
Increased water consumption
Increased urination

Diagnosing Diabetes

The diagnosis of diabetes mellitus is based on three criteria: the four classical clinical signs, the presence of a persistently high level of glucose in the blood stream, and the presence of glucose in the urine.

The normal level of glucose in the blood is 80-120 mg/dl. It may rise to 250-300 mg/dl following a meal. However, diabetes is the only common disease that will cause the blood glucose level to rise above 400 mg/dl. Some diabetic dogs will have a glucose level as high as 800 mg/dl, although most will be in the range of 400-600 mg/dl.

To keep the body from losing its needed glucose, the kidneys do not allow glucose to be filtered out of the blood stream until an excessive level is reached. This means that dogs with a normal blood glucose level will not have glucose in the urine. Diabetic dogs, however, have excessive amounts of glucose in the blood, so it will be present in the urine.

What Diabetes Means to You and Your Dog

For the diabetic dog, one reality exists: blood glucose cannot be normalized without treatment. Although the dog can go a day or so without treatment and not get into a crisis, treatment should be looked upon as part of the dog's daily routine. Treatment almost always requires some dietary changes and administration of insulin.

As for the owner, there are two implications: financial commitment and personal commitment.

When your dog is well regulated, the maintenance costs are minimal. The special diet, insulin, and syringes are not expensive. However, the financial commitment is significant during the initial regulation process and if complications arise.

Initially, your dog may be hospitalized for a few days to deal with the immediate crisis and to begin the regulation process. The "immediate crisis" is only great if your dog is so sick that it has quit eating and drinking for several days. Dogs in this state, called ketoacidosis, may require a week or more of hospitalization with quite a bit of laboratory testing. Otherwise, the initial hospitalization may be only for a day or two to get some testing done and to begin treatment. At that point, your dog goes home for you to administer medication. At first, return visits are required every 5-7 days to monitor progress. It may take a month or more to achieve good regulation.

The financial commitment may again be significant if complications arise. We will work with you to try and achieve consistent regulation, but a few dogs are difficult to keep regulated. It is important that you pay close attention to our instructions related to administration of medication, to diet, and to home monitoring. Another complication that can arise is hypoglycemia, or low blood sugar; if severe, it may be fatal. This may occur due to inconsistencies in treatment. This will be explained in subsequent paragraphs.

Your personal commitment to treating this dog is very important in maintaining regulation and preventing crises. Most diabetic dogs require insulin injections twice daily. They must be fed the same food in the same amount on the same schedule every day. If you are out of town, your dog must receive proper treatment while you are gone. These factors should be considered carefully before deciding to treat a diabetic dog.

Treatment

Consistency is vital to proper management of the diabetic dog. Your dog needs consistent administration of medication, consistent feeding, and a stable, stress-free lifestyle. To best achieve this, it is preferred that your dog live indoors. Although that is not essential, indoor living removes many uncontrollable variables that can disrupt regulation.

Diet
The first step in treatment is to alter your dog's diet. Dogs with diabetes can do well with any diet that is complete and balanced, but diets that are high in fiber are preferred because they are generally lower in sugar and slower to be digested. This means that the dog does not have to process a large amount of sugar at one time. The preferred diets are Prescription Diet Canine w/d, Purina-OM, and Purina-DCO.

Your dog's feeding routine is also important. Some dogs prefer to eat several times per day; however this schedule of feeding makes control of diabetes much more difficult. It is very important that you accurately measure the amount of food that is consumed.

Insulin

The second step in treatment is to use a drug to control (lower) control blood glucose levels . Insulin injections are usually the first choice because this approach is to replace the hormone that is missing or made in inadequate amounts. Many people are initially fearful of giving insulin injections. If this is your initial reaction, consider these points.

1) Insulin does not cause pain when it is injected.
2) The injections are made with very tiny needles that your dog hardly feels.
3) The injections are given just under the skin in areas in which it is almost impossible to cause damage to any vital organ.

Please do not decide whether to treat your dog with insulin until we have demonstrated the injection technique. You will be pleasantly surprised at how easy it is.

Insulin Therapy and Administration

About Insulin

Insulin comes in an airtight bottle that is labeled with the insulin type and the concentration. Before using, mix the contents. It says on the label to roll it gently, not shake it. The reason for this is that insulin has a fragile crystalline structure and vigorous shaking can actually damage the insulin, making it less effective. Some of the types of insulin used in dogs have a strong tendency to settle out of suspension.

Insulin is a hormone that will also lose its effectiveness if exposed to direct sunlight or high temperatures. It should be kept in the refrigerator, but it should not be frozen. It is not ruined if left out of the refrigerator for a day or two as long as it is not exposed to direct sunlight. However, we do not advise this. Insulin is safe as long as it is used as directed, but it should be kept out of reach of children.

Drawing up the Insulin

Have the syringe and needle, insulin bottle, and dog ready. Then, follow these steps:

1) Remove the guard from the needle, and draw back the plunger to the appropriate dose level.
2) Carefully insert the needle into the insulin bottle.
3) Inject air into the bottle; this prevents a vacuum from forming within the bottle.
4) Withdraw the correct amount of insulin into the syringe.

Before injecting your dog with the insulin, check that there are no air bubbles in the syringe. If you get an air bubble, draw twice as much insulin into the syringe as you need. Then withdraw the needle from the insulin bottle and tap the barrel of the syringe with your finger to make the air bubble rise to the nozzle of the syringe. Gently and slowly expel the air bubble by moving the plunger upward.

When this has been done, check that you have the correct amount of insulin in the syringe. The correct dose of insulin can be assured if you measure from the needle end, or "0" on the syringe barrel, to the end of the plunger nearest the needle.

Injecting the Insulin

The steps to follow for injecting insulin are:

1) Hold the syringe in your right hand (switch hands if you are left-handed).
2) Have someone hold your dog while you pick up a fold of skin from somewhere along your dog's back with your free hand (pick up a different spot each day).
3) Quickly push the very sharp, very thin needle through your dog's skin. This should be easy and painless. However, take care to push the needle through only one layer of skin and not into your finger or through two layers of skin. The latter will result in injecting the insulin onto your dog's hair coat or onto the floor. The needle should be directed parallel to the backbone or angled slightly downward.
4) To inject the insulin, place your thumb on the plunger and push it all the way into the syringe barrel.
5) Withdraw the needle from your dog's skin. Immediately place the needle guard over the needle and discard the needle and syringe.
6) Stroke your dog to reward it for sitting quietly.
7) Be aware that some communities have strict rules about disposal of medical waste. Many pharmacies will sell you a sharps container with an agreement for disposal when full.

It is neither necessary nor desirable to swab the skin with alcohol to "sterilize" it. There are four reasons:

1) Due to the nature of the thick hair coat and the type of bacteria that live near the skin of dogs, brief swabbing with alcohol or any other antiseptic is not effective.
2) Because a small amount of alcohol can be carried through the skin by the needle, it may actually carry bacteria with it into the skin.
3) The sting caused by the alcohol can make your dog dislike the injections.
4) If you have accidentally injected the insulin on the surface of the skin, you will not know it. If you do not use alcohol and the skin or hair is wet following an injection, the injection was not done properly.

Although the above procedures may at first seem complicated and somewhat overwhelming, they will very quickly become second nature. Your dog will soon learn that once or twice each day it has to sit still for a few minutes. In most cases, a reward of stroking results in a fully cooperative dog that eventually may not even need to be held.

Monitoring

It is necessary that your dog's progress be checked on a regular basis. Monitoring is a joint project on which owners and veterinarians must work together.

Home Monitoring

Home monitoring can take many forms depending on your comfort level. Oftentimes, many owners find it easier to keep a journal of their dog’s activities. You should be aware of your dog’s appetite, weight, water consumption, and urine output. You should be feeding a constant amount of food each day, which will allow you to be aware of days that your dog does not eat all of it or is unusually hungry after the feeding. You should weigh your dog at least twice monthly. It is best to use the same scales each time.

You should develop a way to measure water consumption. The average dog should drink no more than 7 1/2 oz. (225 ml) of water per 10 pounds (4.5 kg) of body weight per 24 hours. Since this is highly variable from one dog to another, keeping a record of your dog's water consumption for a few weeks will allow you to establish what is normal for your dog.

Any significant change in your dog’s food intake, weight, water intake, or urine output is an indicator that the diabetes is not well controlled. We should see the dog at that time for blood testing.

Another form of home monitoring is to determine the presence of glucose and ketones in the urine. If your dog is properly regulated, there should be no ketones present in the urine. We expect to see some glucose in the urine at times due to fluctuations in the blood sugar throughout the day.

There are several ways to detect glucose and ketones in urine. You may purchase urine glucose test strips in any pharmacy. The most common name for these strips is KetoDiastix. They are designed for use in humans with diabetes, but they will also work in your dog. Urine should be tested at least once a week or whenever you feel that your dog’s diabetes isn’t being properly regulated.

If, at any time, ketones are detected in the urine, please call us as this can be a sign that your dog is becoming ill.

Monitoring of Blood Glucose

Determining the level of glucose in the blood is the most accurate means of monitoring. This can be easily accomplished at home if you have the proper equipment. Home monitor of blood glucoses is often the best way to manage diabetic pets long-term as it eliminates the stress and trouble of bringing your dog to the veterinarian’s office for blood glucose checks. We would be happy to assist you in obtaining a glucometer for home use and instructing you on the correct way to obtain a blood sample. Although this may seem daunting, it is a very simple procedure that is usually well-tolerated by most pets.

During the initial phase of regulating your dog’s diabetes, we will need to perform regular “spot checks” of blood glucose levels to ensure that our insulin dose and schedule is having the desired effect. We will help you determine when these checks should be made. Also, approximately 5-7 days after starting insulin treatment, we will need to perform a blood glucose curve. This is done by giving the insulin at a specified time and taking blood glucose measurements are regular intervals. This can be done in the hospital or at home if you are comfortable with your glucometer.

Once we have achieved good control of your dog’s diabetes, we will work with you to develop a plan for regular monitoring of blood glucoses. It is vitally important that you DO NOT change insulin doses without first consulting with a doctor. Even small changes in dose can have very serious side effects. Too much insulin can cause severe hypoglycemia and even death.


Hypoglycemia

Hypoglycemia means low blood sugar. If it is below 40 mg/dl, it can be life threatening. Hypoglycemia occurs under two conditions:

1) If the insulin dose is too high. Although most dogs will require the same dose of insulin for long periods of time, it is possible for the dog's insulin requirements to change. However, the most common causes for change are a reduction in food intake and an increase in exercise or activity. The reason for feeding before the insulin injection is so you can know when the appetite changes. If your dog does not eat, skip that dose of insulin. If only half of the food is eaten just give a half dose of insulin. Always remember that it is better for the blood sugar to be too high than too low.

2) If too much insulin is given. This can occur because the insulin was not properly measured in the syringe or because two doses were given. You may forget that you gave it and repeat it, or two people in the family may each give a dose. A chart to record insulin administration will help to prevent the dog being treated twice.

The most likely time that a dog will become hypoglycemic is the time of peak insulin effect (5-8 hours after an insulin injection). When the blood glucose is only mildly low, the dog will be very tired and unresponsive. You may call it and get no response. Within a few hours, the blood glucose will rise, and your dog will return to normal. Since many dogs sleep a lot during the day, this important sign is easily missed. Watch for it; it is the first sign of impending problems. If you see it, please bring in your dog for blood testing.

If your dog is slow to recover from this period of lethargy, you should give it corn syrup (1 tablespoon per 10 pounds of body weight by mouth). If there is no response in 15 minutes, repeat the corn syrup. If there is still no response, contact us immediately for further instructions.

***If severe hypoglycemia occurs, a dog will have seizures or lose consciousness. This is an emergency that can only be reversed with intravenous administration of glucose. If it occurs during office hours, come in immediately. If it occurs at night or on the weekend, call our emergency phone number for instructions.***


Monitoring Summary

Ongoing Home Monitoring for All Dogs
 Log food, water and appetite daily
 Log insulin dose daily
 Note any signs of hypoglycemia (Alert veterinarian if persistent)
 Periodically test urine

During the first month after initiating insulin treatment
 Weekly (every 7 to 10 days)
   o Recheck examination +/- blood glucose curve
   o Will be continued until clinical signs are controlled and results of blood testing suggest control
   o Insulin may be adjusted by your veterinarian

Long-term monitoring of insulin treatment
 Every 3 months:
   o Examination, including weight and eye examination
   o Measure blood glucose, fructosamine levels
   o Blood glucose curves will be performed if any problems or if insulin dose is changed
 Every 6 months
   o Full laboratory work including urinalysis and urine culture
   o Any of the above that cannot be performed at home

Blood Glucose Curve Instructions
 Please do not perform blood glucose curves without direction of your veterinarian.
 After you obtain the results of the curve, please contact your veterinarian for interpretation and further instructions regarding changes in insulin therapy. There will be a    consultation fee for this. DO NOT MAKE ANY CHANGES TO THE INSULIN DOSE WITHOUT CONSULTING YOUR VETERINARIAN.
 Procedure:
      1. Obtain a blood glucose prior to feeding your dog or administering insulin
      2. Feed your dog’s normal meal and administer insulin after he/she has eaten
      3. Measure a blood glucose every 2 hours (if on PZI) for up to 10-12 hours. Ideally values should be obtained up until next insulin dose is due.
      4. Contact our office with results.